CLINICAL AND GENOMIC CHARACTERIZATION OF CHEMORADIATION-RESISTANT HPV-POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

Clinical and genomic characterization of chemoradiation-resistant HPV-positive oropharyngeal squamous cell carcinoma

IntroductionMost patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) have an excellent response to chemoradiation, and trials are now investigating de-escalated treatment.However, up to 25% of patients with HPV-positive OPSCC will experience recurrence, and up to 5% will even progress through primary treatment.Currently, there

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Locality in Language and Locality in Brain Oscillatory Structures

From the perspective of brain oscillations, an explanation is offered as to why external systems of language cannot deal with identical categorial elements in certain local domains.An equivalent Baby Gym locality effect in brain structure is argued for which causes a (cognitively problematic and ambiguous) synchronization of rhythms in the gamma, b

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